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KMID : 0606920150230010012
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Biomolecules & Therapeutics
2015 Volume.23 No. 1 p.12 ~ p.18
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Keratinocytic Vascular Endothelial Growth Factor as a Novel Biomarker for Pathological Skin Condition
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Bae Ok-Nam
Noh Min-Soo
Chun Young-Jin
Jeong Tae-Cheon
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Abstract
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Skin is an emerging target tissue in pharmaceutical and cosmetic science. Safety assessment for dermal toxicity is a critical step for development of topically applicable pharmaceutical agents and ingredients in cosmetics. Urgent needs exist to set up toxicity testing methods for dermal safety, and identification of novel biomarkers for pathological cutaneous alteration is highly required. Here we will discuss if vascular endothelial growth factor (VEGF) has a potential as a biomarker for dermal impairment. Experimental and clinical evidences for induction of keratinocytic VEGF under pathological conditions will be reviewed.
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KEYWORD
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Vascular endothelial growth factor (VEGF), Biomarker, Keratinocytic damage, Dermal toxicity
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